Many affected individuals with (RCE) exhibit symptoms for years and tend to experience poor treatment outcomes. Published research outlines a particular treatment cocktail that is proven to be effective.
One study indicated that the enzyme responsible for RCE is matrix metalloproteinase-9 (MMP-9). Furthermore, the researchers documented that corticosteroids and oral doxycycline inhibit production of this enzyme. Also, other medications, such as AzaSite (azithromycin) have been shown to inhibit MMP-9.
Also, because almost all cases of RCE occur overnight… likely due to an increase in corneal edema during sleep, bedtime use of hypertonic therapeutic ointments, such as Muro 128 ointment (sodium chloride hypertonicity ophthalmic solution 5.0%, Bausch + Lomb), is recommended.²
FreshKote (Focus Laboratories), a newer prescription artificial tear for moderate to severe dry eye, also appears to work well for patients with recalcitrant RCE.